The effect of metformin on cardiovascular markers in female mice consuming a high fat diet

N de Alwis; NK Binder; YTM Mangwiro; N Pritchard; S Beard; TJ Kaitu'u-Lino; F Brownfoot; NJ Hannan

Journal article

The effect of metformin on cardiovascular markers in female mice consuming a high fat diet

N de Alwis, NK Binder, YTM Mangwiro, N Pritchard, S Beard, TJ Kaitu'u-Lino, F Brownfoot, NJ Hannan

Obesity Research and Clinical Practice | ELSEVIER SCI LTD | Published : 2022

DOI: 10.1016/j.orcp.2022.10.006

Abstract

Background: Metformin, widely used to treat diabetes, is now considered a candidate therapeutic for treatment of cardiovascular disease. This study aimed to assess whether metformin's non-glycaemic effects could mitigate cardiovascular disease indices in female mice consuming a high fat diet (HFD). Methods: Four-week old female Arc:Arc(S) mice were placed on a standard (std) chow diet or Western-style HFD (22% fat, 0.15% cholesterol). At ∼8 months, the mice were administered 150 mg/kg metformin or vehicle (control) via intraperitoneal injection for 11 days. Blood pressure was measured (tail cuff plethysmography) at Day 9 and 11 of treatment. On Day 11, mice were weighed and culled. The mesen..

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University of Melbourne Researchers

Natasha de Alwis Author

Natalie Binder Author

Yeukai Mangwiro Author

Natasha Pritchard Author

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Grants

Awarded by National Jewish Health

Funding Acknowledgements

This work was supported by a RANZCOG Women's Health Foundation Research Scholarship (NP). Salary support was provided by the National Health and Medical Research Council Fellowships to NP (#1150828), TKL (#1159261), FB(#1142636) and NJH (#1146128). The funders played no role in study design or analysis.